Holyoke has been home to a handful of minor league and collegiate baseball teams.

Among the first was the Holyoke Paperweights of the Connecticut League from 1903 to 1911.

The Holyoke Millers, a Double-A team, moved to the city following a single season in Pittsfield as the Berkshire Brewers. 

The Holyoke Giants, a Futures Collegiate Baseball League Team.

The Valley Blue Sox, a member of the New England Collegiate Baseball League who currently uses Holyoke Highschools Makenzie Stadium as their Home Field.